News and Views

Two Reviews published!

The first is a perspective of our grand goals in building bioenergetic proteins and circuits from scratch, and an overview of our current de novo modules. Importantly, this review gives a summary of what we think are the main outstanding challenges. Read more here: Building tailor-made bioenergetic proteins and circuits from de novo redox proteins The second…
Single-heme de novo proteins enable the dissection of redox cooperativity in diheme cytochromes

We recently reported our work constructing single-heme proteins from our water-soluble and transmembrane diheme proteins 4D2 and CytbX. Whilst we initially set out to make these proteins for ‘completionist’ reasons, we realised we could use them to gather valuable insights to the factors that lead to redox potential splitting in our diheme proteins. Read the…
Fluctuation Relations to Calculate Protein Redox Potentials from Molecular Dynamics Simulations

We are excited to share a new tool, dubbed MD+CB, to calculate protein redox potentials based on fluctuation relations extracted from molecular dynamics simulations of heme proteins Spearheaded by Sofia Oliveira, Ross Anderson and Adrian Mullholland from the Circuits of Life project, this novel method was tested on point mutants (designed by past PhD student…
Congratulations to Ethan Bungay! Poster Prize winner

Congratulations to PhD student Ethan Bungay for winning the Best Poster Prize at this year’s Christmas Bioenergetics Meeting in York – well deserved!
4D2 Paper: Press-release from the University of Bristol

Pioneering study signals new era of environment-friendly programmable bioelectronics The University of Bristol have published a press release on our recent publication describing the design of 4D2, m4D2 and e4D2 “While our designs take inspiration from the protein-based electronic circuits necessary for all life on Earth, they are free from much of the complexity and…
Prof. Ross Anderson is giving the keynote talk at this year’s Christmas Bioenergetics Meeting!

We are all excited to attend this year’s Annual Christmas Bioenergetics Meeting, hosted by the University of York and the Biochemical Society. Prof Ross Anderson will provide a keynote talk on his group’s efforts to build cytochromes/bioenergetic systems from scratch (see https://pubmed.ncbi.nlm.nih.gov/37487099/ & https://pubmed.ncbi.nlm.nih.gov/37036998/) and the rest of the day will be dedicated to talks from early career…