Circuits of Life

The first is a perspective of our grand goals in building bioenergetic proteins and circuits from scratch, and an overview of our current de novo modules.

Importantly, this review gives a summary of what we think are the main outstanding challenges.

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Building tailor-made bioenergetic proteins and circuits from de novo redox proteins

The second is a focussed review of the state-of-the-art methods for designing bioenergetic membrane protein modules, and the goals of ‘synthetic bioenergetics’

Here we discuss our successes with CytbX, highlight important acheivements in the field, and also outline existing challenges and future perspectives.

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Computational design of de novo bioenergetic membrane proteins